Was Scotland deglaciated during the Younger Dryas?

Recent work has produced data that challenges the canonical view that the Younger Dryas (c.12.9–11.7 ka) was a time of glacier expansion across the North Atlantic. Boulders on moraines located within the inner sector of the Scottish Loch Lomond Stadial (≈Younger Dryas) ice cap yield cosmogenic exposure ages 12.8–11.3 ka with a best estimate moraine age of 11.5 ± 0.6 ka. This age contradicts the interpretation that Scotland was completely deglaciated as early as 12,580 cal yr BP and no later than 12,200 cal yr BP. Our data supports the previously accepted scenario, supported by a wide variety of data, that final deglaciation of Scotland did not occur until late in the Loch Lomond Stadial or the early Holocene

The deglaciation of the northwest sector of the last British-Irish ice sheet : integrating onshore and offshore data relating to chronology and behaviour

It is now accepted that the last British-Irish Ice Sheet (BIIS) was highly dynamic and drained by numerous fast flowing ice streams. This dynamic nature combined with its maritime location made the BIIS sensitive to the rapid climate change that characterised the Last Glacial Interglacial Transition. Gaining an understanding of the behaviour of the BIIS at this time is important to explore the nature of forcing between ice sheets and climate. This thesis presents new chronological data relating to the deglaciation of the northwest sector of the BIIS (NW-BIIS) from onshore dating of moraines using cosmogenic exposure dating. This improved chronological framework is supported by offshore data in the form of a newly constructed Ice Rafted Detritus (IRD) record from the offshore sediment core MD95-2007. These data suggest that deglaciation commenced sometime after 18 ka and that the NW-BIIS was located close to the present day shoreline by 16 ka. Further provenance analysis of the IRD using U-Pb dating of detrital minerals demonstrates that during the Last Glacial-Interglacial Transition MD95-2007 was being supplied distal IRD from a source(s) to the west. The absence of diagnostic Scottish material suggests that after retreat to the coastline at 16 ka calving margins were not re-established during Greenland Interstadial 1. By combining these results with existing data relating to the deglaciation of the NW-BIIS it is possible to summarise the deglaciation history of the NW-BIIS from the continental shelf to mountainous source regions and compare this to numerical models of BIIS behaviour during this time. With a better understanding of the chronology of NW-BIIS retreat it is possible to relate the timing of initial deglaciation to possible forcing factors and gain a better understanding of the response of a marine based sector of an ice sheet to rapid climate change

Nowcasting GDP and Inflation: The Real-Time Informational Content of Macroeconomic Data Releases

This paper formalizes the process of updating the nowcast and forecast on out-put and inflation as new releases of data become available. The marginal contribution of a particular release for the value of the signal and its precision is evaluated by computing "news" on the basis of an evolving conditioning information set. The marginal contribution is then split into what is due to timeliness of information and what is due to economic content. We find that the Federal Reserve Bank of Philadelphia surveys have a large marginal impact on the nowcast of both inflation variables and real variables and this effect is larger than that of the Employment Report. When we control for timeliness of the releases, the effect of hard data becomes sizeable. Prices and quantities affect the precision of the estimates of inflation while GDP is only affected by real variables and interest rates

Nowcasting GDP and inflation: the real-time informational content of macroeconomic data releases

This paper formalizes the process of updating the nowcast and forecast on output and inflation as new releases of data become available. The marginal contribution of a particular release for the value of the signal and its precision is evaluated by computing "news" on the basis of an evolving conditioning information set. The marginal contribution is then split into what is due to timeliness of information and what is due to economic content. We find that the Federal Reserve Bank of Philadelphia surveys have a large marginal impact on the nowcast of both inflation variables and real variables and this effect is larger than that of the Employment Report. When we control for timeliness of the releases, the effect of hard data becomes sizeable. Prices and quantities affect the precision of the estimates of inflation while GDP is only affected by real variables and interest rates. JEL Classification: E52, C33, C53factor model, forecasting, Large Data Sets, monetary policy, news, Real Time Data

Establishing the relationship of inhaler satisfaction, treatment adherence, and patient outcomes : A prospective, real-world, cross-sectional survey of US adult asthma patients and physicians

Date of Acceptance: 26/06/2015 Acknowledgements The disease-specific program, on which the analyses were based, was designed and run by Adelphi Real World. The program was supported by a number of pharmaceutical companies, including Meda Pharmaceuticals. This specific analysis, together with this publication, was supported by Meda Pharmaceuticals. The decision to publish was made jointly by all authors cited. Medical writing support and literature searching was provided by Carole Alison Chrvala, PhD of Health Matters, Inc.Peer reviewedPublisher PD

Historical cohort study examining comparative effectiveness of albuterol inhalers with and without integrated dose counter for patients with asthma or chronic obstructive pulmonary disease

This study was supported financially by an unrestricted grant from Teva Pharmaceuticals, Frazer, PA, USA. The authors thank Jenny Fanstone of Fanstone Medical Communications Ltd., UK, and Elizabeth V Hillyer for medical writing support, funded by Research in Real-Life. We acknowledge with gratitude Dr Ruchir Parikh for his review of and contributions to the manuscript.Peer reviewedPublisher PD